Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.

Terje Andersen, Jan; Dalhus, Bjørn; Viuff, Dorthe; Thue Ravn, Birgitte; Støen Gunnarsen, Kristin; Plumridge, Andrew; Bunting, Karen; Antunes, Filipa; Williamson, Rebecca; Athwal, Steven; Allan, Elizabeth; Evans, Leslie; Bjørås, Magnar; Kjærulff, Søren; Sleep, Darrell; Sandlie, Inger; Cameron, Jason

doi:10.1074/jbc.m114.549832

Public

Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.

Shared by NobleBlocks on May 9, 2014 • 12:00 AM UTC

Authors:

Jan Terje Andersen

Bjørn Dalhus

Dorthe Viuff

Abstract

A major challenge for the therapeutic use of many peptides and proteins is their short circulatory half-life. Albumin has an extended serum half-life of 3 weeks because of its size and FcRn-mediated recycling that prevents intracellular degradation, properties shared with IgG antibodies. Engineering...

Subject

Albumin

Animal Models

Antibody Engineering

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