Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).

OG, Ottmann; B, Wassmann; H, Pfeifer; A, Giagounidis; M, Stelljes; U, Dührsen; M, Schmalzing; L, Wunderle; A, Binckebanck; D, Hoelzer

doi:10.1002/cncr.22631

Public

Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).

Shared by NobleBlocks on May 1, 2007 • 12:00 AM UTC

Authors:

Ottmann OG

Wassmann B

Pfeifer H

Abstract

<h4>Background</h4>Elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) have a poor prognosis, with a low complete remission (CR) rate, high induction mortality, and short remission duration. Imatinib (IM) has a favorable toxicity profile but limited antileuke...

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