Overexpression of CD133 enhances chemoresistance to 5-fluorouracil by activating the PI3K/Akt/p70S6K pathway in gastric cancer cells.

Zhu, Youlong; Yu, Jiwei; Wang, Shoulian; Lu, Ruiqi; Wu, Jugang; Jiang, Bojian

doi:10.3892/or.2014.3488

Public

Overexpression of CD133 enhances chemoresistance to 5-fluorouracil by activating the PI3K/Akt/p70S6K pathway in gastric cancer cells.

Shared by NobleBlocks on Dec 1, 2014 • 12:00 AM UTC

Authors:

Youlong Zhu

Jiwei Yu

Shoulian Wang

Abstract

CD133 has been reported to be associated with chemoresistance in various cancer cells. The efficacy of 5-fluorouracil (5-FU), an important chemotherapeutic agent for advanced gastric cancer (GC), is limited by 5-FU resistance. Hence, the present study investigated the function of CD133 in 5-FU resis...

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