Transmission of hepatitis A to patients with hemophilia by factor VIII concentrates treated with organic solvent and detergent to inactivate viruses. The Italian Collaborative Group.

PM, Mannucci; S, Gdovin; A, Gringeri; M, Colombo; A, Mele; N, Schinaia; N, Ciavarella; SU, Emerson; RH, Purcell

doi:10.7326/0003-4819-120-1-199401010-00001

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Transmission of hepatitis A to patients with hemophilia by factor VIII concentrates treated with organic solvent and detergent to inactivate viruses. The Italian Collaborative Group.

Shared by NobleBlocks on Jan 1, 1994 • 12:00 AM UTC

Authors:

Mannucci PM

Gdovin S

Gringeri A

Abstract

<h4>Objective</h4>To determine whether an outbreak of hepatitis A virus (HAV) infection that occurred in 52 patients with hemophilia in Italy was acquired through infusion of contaminated factor VIII or through environmental enteric transmission.<h4>Design</h4>A case-control study and a molecular an...

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