SHP-2 Tyrosine Phosphatase as an Intracellular Target of
                    <i>Helicobacter pylori</i>
                    CagA Protein

Higashi, Hideaki; Tsutsumi, Ryouhei; Muto, Syuichi; Sugiyama, Toshiro; Azuma, Takeshi; Asaka, Masahiro; Hatakeyama, Masanori

doi:10.1126/science.1067147

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SHP-2 Tyrosine Phosphatase as an Intracellular Target of <i>Helicobacter pylori</i> CagA Protein

Shared by NobleBlocks on Jan 25, 2002 • 12:00 AM UTC

Authors:

Hideaki Higashi

Ryouhei Tsutsumi

Syuichi Muto

Abstract

Helicobacter pylori CagA protein is associated with severe gastritis and gastric carcinoma. CagA is injected from the attached Helicobacter pylori into host cells and undergoes tyrosine phosphorylation. Wild-type but not phosphorylation-resistant CagA induced a growth factor–like response in gastric...

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