Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.

Tohen, Mauricio; N Roy Chengappa, K; Suppes, Trisha; A Zarate, Carlos; R Calabrese, Joseph; L Bowden, Charles; S Sachs, Gary; J Kupfer, David; W Baker, Robert; C Risser, Richard; L Keeter, Elisabeth; D Feldman, Peter; D Tollefson, Gary; Breier, Alan

doi:10.1001/archpsyc.59.1.62

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Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.

Shared by NobleBlocks on Jan 1, 2002 • 12:00 AM UTC

Authors:

Mauricio Tohen

K N Roy Chengappa

Trisha Suppes

Abstract

BACKGROUND: A 6-week double-blind, randomized, placebo-controlled trial was conducted to determine the efficacy of combined therapy with olanzapine and either valproate or lithium compared with valproate or lithium alone in treating acute manic or mixed bipolar episodes. METHODS: The primary objecti...

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