Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.

H, Liu; D, Chao; EE, Nakayama; H, Taguchi; M, Goto; X, Xin; JK, Takamatsu; H, Saito; Y, Ishikawa; T, Akaza; T, Juji; Y, Takebe; T, Ohishi; K, Fukutake; Y, Maruyama; S, Yashiki; S, Sonoda; T, Nakamura; Y, Nagai; A, Iwamoto; T, Shioda

doi:10.1073/pnas.96.8.4581

Public

Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.

Shared by NobleBlocks on Apr 1, 1999 • 12:00 AM UTC

Authors:

Liu H

Chao D

Nakayama EE

Abstract

RANTES (regulated on activation normal T cell expressed and secreted) is one of the natural ligands for the chemokine receptor CCR5 and potently suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Previous studies showed that peripheral blood mononuclear cells...

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