Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

W Kinzler, K; C Nilbert, M; Vogelstein, B; M Bryan, T; B Levy, D; J Smith, K; C Preisinger, A; R Hamilton, S; Hedge, P; Markham, A

doi:10.1126/science.1848370

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Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

Shared by NobleBlocks on Mar 15, 1991 • 12:00 AM UTC

Authors:

K W Kinzler

M C Nilbert

B Vogelstein

Abstract

Recent studies have suggested the existence of a tumor suppressor gene located at chromosome region 5q21. DNA probes from this region were used to study a panel of sporadic colorectal carcinomas. One of these probes, cosmid 5.71, detected a somatically rearranged restriction fragment in the DNA from...

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