The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.

Xu, Xun; Nagarajan, Harish; E Lewis, Nathan; Pan, Shengkai; Cai, Zhiming; Liu, Xin; Chen, Wenbin; Xie, Min; Wang, Wenliang; Hammond, Stephanie; R Andersen, Mikael; Neff, Norma; Passarelli, Benedetto; Koh, Winston; Christina Fan, H; Wang, Jianbin; Gui, Yaoting; H Lee, Kelvin; J Betenbaugh, Michael; R Quake, Stephen; Famili, Iman; O Palsson, Bernhard; Wang, Jun

doi:10.1038/nbt.1932

Public

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.

Shared by NobleBlocks on Jul 31, 2011 • 12:00 AM UTC

Authors:

Xun Xu

Harish Nagarajan

Nathan E Lewis

Abstract

Chinese hamster ovary (CHO)-derived cell lines are the preferred host cells for the production of therapeutic proteins. Here we present a draft genomic sequence of the CHO-K1 ancestral cell line. The assembly comprises 2.45 Gb of genomic sequence, with 24,383 predicted genes. We associate most of th...

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