Direct Regulation of the
            <i>Akt</i>
            Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

F. Franke, Thomas; R. Kaplan, David; C. Cantley, Lewis; Toker, Alex

doi:10.1126/science.275.5300.665

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Direct Regulation of the <i>Akt</i> Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

Shared by NobleBlocks on Jan 28, 1997 • 12:00 AM UTC

Authors:

Thomas F. Franke

David R. Kaplan

Lewis C. Cantley

Abstract

The regulation of the serine-threonine kinase Akt by lipid products of phosphoinositide 3-kinase (PI 3-kinase) was investigated. Akt activity was found to correlate with the amount of phosphatidylinositol-3,4-bisphosphate (PtdIns-3,4-P 2 ) in vivo, and synthetic PtdIns-3,4-P 2 activated Akt both in ...

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