A functional test identifies dopamine agonists selective for D3 versus D2 receptors

Sautel, François; Griffon, Nathalie; Lévesque, Daniel; Pilon, Catherine; Schwartz, J.C.; Sokoloff, Pierre

doi:10.1097/00001756-199501000-00026

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A functional test identifies dopamine agonists selective for D3 versus D2 receptors

Published in Neuroreport • Jan 1, 1995

Authors:

François Sautel

Nathalie Griffon

Daniel Lévesque

Abstract

The functional potency of a series of dopamine agonists for increasing mitogenesis, measured by incorporation of [3H]thymidine, was established in transfected cell lines expressing human D2 or D3 receptors. The functional selectivity of agonists markedly differs from their binding selectivity. (+)7-...

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Subject

Dopamine receptor D3

Pramipexole

Dopamine receptor D2

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