Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents.

H, Kobayashi; S, Kawamoto; T, Saga; N, Sato; A, Hiraga; T, Ishimori; J, Konishi; K, Togashi; MW, Brechbiel

doi:10.1002/mrm.1257

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Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents.

Shared by NobleBlocks on Oct 1, 2001 • 12:00 AM UTC

Authors:

Kobayashi H

Kawamoto S

Saga T

Abstract

Macromolecules conjugated with polyethylene glycol (PEG) acquire more hydrophilicity, resulting in a longer half-life in circulation and lower immunogenicity. Two novel conjugates for MRI contrast agents were synthesized from a generation-4 polyamidoamine dendrimer (G4D), 2-(p-isothiocyanatobenzyl)-...

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