Новый противоопухолевый препарат морфозол: внутриклеточное распределение и влияние на синтез ДНК
Published in Российский биотерапевтический журнал • Jan 1, 2008
Authors:,,
Л. Б. Горбачева
А. Г. Тихомиров
Л. Ю. Дедерер
Abstract
In vitro study of the interaction of DNA with morfozol-a new palladium(II) acidocomplex- revealed the active binding of the drug to DNA, which was manifested by a decrease of the accessibility of DNA for actinomycin D. Morfozol produced strong and stable suppression of DNA synthesis in leukemia L121...