Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes--conclusions from the 3rd International ESTP Expert Workshop.

AP, Hall; CR, Elcombe; JR, Foster; T, Harada; W, Kaufmann; A, Knippel; K, Küttler; DE, Malarkey; RR, Maronpot; A, Nishikawa; T, Nolte; A, Schulte; V, Strauss; MJ, York

doi:10.1177/0192623312448935

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Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes--conclusions from the 3rd International ESTP Expert Workshop.

Shared by NobleBlocks on Jun 21, 2012 • 12:00 AM UTC

Authors:

Hall AP

Elcombe CR

Foster JR

Abstract

Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a signature of toxicological changes characterized by an increase in liver weight, hepatocellular hypertrophy, cell proliferation, and, frequent...

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