Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.

JM, Yang; P, O'Neill; W, Jin; R, Foty; DJ, Medina; Z, Xu; M, Lomas; GM, Arndt; Y, Tang; M, Nakada; L, Yan; WN, Hait

doi:10.1074/jbc.m508421200

Public

Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.

Shared by NobleBlocks on Jan 27, 2006 • 12:00 AM UTC

Authors:

Yang JM

O'Neill P

Jin W

Abstract

Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, promotes invasion, metastasis, and growth and survival of malignant cells and confers resistance to some chemotherapeu...

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