Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type.

Z, Gatalica; C, Snyder; T, Maney; A, Ghazalpour; DA, Holterman; N, Xiao; P, Overberg; I, Rose; GD, Basu; S, Vranic; HT, Lynch; Hoff DD, Von; O, Hamid

doi:10.1158/1055-9965.epi-14-0654

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Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type.

Shared by NobleBlocks on Nov 12, 2014 • 12:00 AM UTC

Authors:

Gatalica Z

Snyder C

Maney T

Abstract

Cancer cells expressing PD-1 ligands (PD-L1/PD-L2) inhibit immune-modulatory T-cell activation facilitating disease progression. Preliminary clinical trials exploring interruption of PD-1/PD-L1 signaling showed benefit in several cancer types. We analyzed the distribution of PD-1-positive tumor-infi...

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