Red blood cells express a functional endothelial nitric oxide synthase.

P, Kleinbongard; R, Schulz; T, Rassaf; T, Lauer; A, Dejam; T, Jax; I, Kumara; P, Gharini; S, Kabanova; B, Ozüyaman; HG, Schnürch; A, Gödecke; AA, Weber; M, Robenek; H, Robenek; W, Bloch; P, Rösen; M, Kelm

doi:10.1182/blood-2005-10-3992

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Red blood cells express a functional endothelial nitric oxide synthase.

Shared by NobleBlocks on Dec 20, 2005 • 12:00 AM UTC

Authors:

Kleinbongard P

Schulz R

Rassaf T

Abstract

The synthesis of nitric oxide (NO) in the circulation has been attributed exclusively to the vascular endothelium. Red blood cells (RBCs) have been demonstrated to carry a nonfunctional NO synthase (NOS) and, due to their huge hemoglobin content, have been assumed to metabolize large quantities of N...

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