A Double-Blind, Randomized Phase II Study to Evaluate the Safety and Efficacy of Acetyl-L-Carnitine in the Prevention of Sagopilone-Induced Peripheral Neuropathy

Campone, Mario; Berton-Rigaud, Dominique; Joly‐Lobbedez, Florence; Baurain, Jean‐François; Rolland, Frédéric; Stenzl, Arnulf; Fabbro, Michel; Dijk, Marjan; Pinkert, Jörg; Schmelter, Thomas; de Bont, Natasja; Pautier, Patricia

doi:10.1634/theoncologist.2013-0061

Public

A Double-Blind, Randomized Phase II Study to Evaluate the Safety and Efficacy of Acetyl-L-Carnitine in the Prevention of Sagopilone-Induced Peripheral Neuropathy

Published in The Oncologist • Oct 8, 2013

Authors:

Mario Campone

Dominique Berton-Rigaud

Florence Joly‐Lobbedez

Abstract

Peripheral neuropathy (PN) is a recognized side effect of microtubule-targeting agents and the most clinically relevant toxicity observed with the epothilone sagopilone (SAG). Studies suggest that acetyl-L-carnitine (ALC) may prevent chemotherapy-induced PN. We conducted a prospective, placebo (PBO)...

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Open Access

Subject

Medicine

Peripheral neuropathy

Internal medicine

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