Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson's disease models are mediated by GPR109A-dependent mechanisms.

SP, Fu; JF, Wang; WJ, Xue; HM, Liu; BR, Liu; YL, Zeng; SN, Li; BX, Huang; QK, Lv; W, Wang; JX, Liu

doi:10.1186/s12974-014-0230-3

Public

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson's disease models are mediated by GPR109A-dependent mechanisms.

Shared by NobleBlocks on Jan 17, 2015 • 12:00 AM UTC

Authors:

Fu SP

Wang JF

Xue WJ

Abstract

<h4>Background</h4>Accumulating evidence suggests that neuroinflammation plays an important role in the progression of Parkinson's disease (PD). Excessively activated microglia produce several pro-inflammatory enzymes and pro-inflammatory cytokines, leading to damage to surrounding neurons and event...

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