Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

V, Alterio; M, Hilvo; Fiore A, Di; CT, Supuran; P, Pan; S, Parkkila; A, Scaloni; J, Pastorek; S, Pastorekova; C, Pedone; A, Scozzafava; SM, Monti; Simone G, De

doi:10.1073/pnas.0908301106

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Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Published in Proceedings of the National Academy of Sciences of the United States of America • Sep 14, 2009

Authors:

Alterio V

Hilvo M

Di Fiore A

Abstract

Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the alpha-CA enzyme family, which is involved in solid tumor acidification. It is a marker of tumor hypoxia and a prognostic factor in several human cancers. An aberrant increase in CA IX expression in chronic hypoxia and during de...

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