The diarylquinoline TMC207 for multidrug-resistant tuberculosis.

AH, Diacon; A, Pym; M, Grobusch; R, Patientia; R, Rustomjee; L, Page-Shipp; C, Pistorius; R, Krause; M, Bogoshi; G, Churchyard; A, Venter; J, Allen; JC, Palomino; Marez T, De; Heeswijk RP, van; N, Lounis; P, Meyvisch; J, Verbeeck; W, Parys; Beule K, de; K, Andries; Neeley DF, Mc

doi:10.1056/nejmoa0808427

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The diarylquinoline TMC207 for multidrug-resistant tuberculosis.

Shared by NobleBlocks on Jun 1, 2009 • 12:00 AM UTC

Authors:

Diacon AH

Pym A

Grobusch M

Abstract

<h4>Background</h4>The diarylquinoline TMC207 offers a new mechanism of antituberculosis action by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and shows bactericidal activity in patients who have drug-susceptib...

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