The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.

Ohuchi, H; Nakagawa, T; Yamamoto, A; Araga, A; Ohata, T; Ishimaru, Y; Yoshioka, H; Kuwana, T; Nohno, T; Yamasaki, M; Itoh, N; Noji, S

doi:10.1242/dev.124.11.2235

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The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.

Shared by NobleBlocks on Jun 1, 1997 • 12:00 AM UTC

Authors:

H Ohuchi

T Nakagawa

A Yamamoto

Abstract

Vertebrate limb formation has been known to be initiated by a factor(s) secreted from the lateral plate mesoderm. In this report, we provide evidence that a member of the fibroblast growth factor (FGF) family, FGF10, emanates from the prospective limb mesoderm to serve as an endogenous initiator for...

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