Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine.

B, García; E, Neninger; la Torre A, de; I, Leonard; R, Martínez; C, Viada; G, González; Z, Mazorra; A, Lage; T, Crombet

doi:10.1158/1078-0432.ccr-07-1050

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Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine.

Shared by NobleBlocks on Feb 1, 2008 • 12:00 AM UTC

Authors:

García B

Neninger E

de la Torre A

Abstract

<h4>Purpose</h4>Epidermal growth factor (EGF) might be a suitable immunotherapeutic target in non-small-cell lung cancer (NSCLC). Our approach consists of active immunotherapy with EGF. The aim of the study is to characterize the humoral response and its effects on signal transduction in relation wi...

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