Sorafenib Inhibits Non–Small Cell Lung Cancer Cell Growth by Targeting B-RAF in <i>KRAS</i> Wild-Type Cells and C-RAF in <i>KRAS</i> Mutant Cells

Sorafenib is a multikinase inhibitor whose targets include B-RAF and C-RAF, both of which function in the extracellular signal-regulated kinase (ERK) signaling pathway but which also have distinct downstream targets. The relative effects of sorafenib on B-RAF and C-RAF signaling in tumor cells remai... View More