Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.

Kolossov, Eugen; Bostani, Toktam; Roell, Wilhelm; Breitbach, Martin; Pillekamp, Frank; M Nygren, Jens; Sasse, Philipp; Rubenchik, Olga; W U Fries, Jochen; Wenzel, Daniela; Geisen, Caroline; Xia, Ying; Lu, Zhongju; Duan, Yaqi; Kettenhofen, Ralf; Jovinge, Stefan; Bloch, Wilhelm; Bohlen, Heribert; Welz, Armin; Hescheler, Juergen; Eirik Jacobsen, Sten; K Fleischmann, Bernd

doi:10.1084/jem.20061469

Public

Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.

Shared by NobleBlocks on Oct 2, 2006 • 12:00 AM UTC

Authors:

Eugen Kolossov

Toktam Bostani

Wilhelm Roell

Abstract

Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which is the most promising cell source. Therefore, we investigated and examined the fate and functional impact of bone marrow (BM) cells and embryonic stem cel...

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