Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Escott-Price, V.; Bellenguez, C.; Wang, Li-San; Choi, S.; Harold, D.; Jones, L.; Holmans, P.; Gerrish, A.; Vedernikov, Alexey; Richards, A.; Destefano, A.; Lambert, J.; Ibrahim-Verbaas, C.; Naj, A.; Sims, R.; Jun, G.; Bis, J.; Beecham, G.; Grenier‐Boley, B.; Russo, G.; Thornton-Wells, T.; Denning, N.; Smith, A.; Chouraki, V.; Thomas, C.; Ikram, M.; Zélénika, D.; Vardarajan, B.; Kamatani, Y.; Lin, Chiao-Feng; Schmidt, H.; Kunkle, B.; Dunstan, M.; Vronskaya, M.; D. Johnson, Andrew; Ruiz, A.; Bihoreau, M.; Reitz, C.; Pasquier, F.; Hollingworth, P.; Hanon, O.; Fitzpatrick, A.; Buxbaum, J.; Campion, D.; Crane, P.; Baldwin, C.; Becker, T.; Gudnason, V.; Cruchaga, C.; Craig, D.; Amin, N.; Berr, C.; Lopez, O.; D. De Jager, P.; Deramecourt, V.; Johnston, J.; Evans, D.; Lovestone, S.; Letenneur, L.; Hernández, I.; Rubinsztein, D.; Eiriksdottir, G.; Sleegers, K.; Goate, A.; Fievet, N.; Huentelman, M.; Gill, M.; Brown, K.; Kamboh, M.; Keller, L.; Barberger‐Gateau, P.; McGuinness, B.; Larson, E.; Myers, A.; Dufouil, C.; Todd, S.; Wallon, D.; Love, S.; Rogaeva, E.; Gallacher, J.; George-Hyslop, P.; Clarimón, J.; Lleó, A.; Bayer, A.; Tsuang, D.; Yu, Lei; Tsolaki, M.; Bossù, P.; Spalletta, G.; Proitsi, P.; Collinge, J.; Sorbi, S.; Sanchez Garcia, Florentino; C Fox, Nick; Hardy, J.; Naranjo, M.; Bosco, P.; Clarke, R.; Brayne, C.; Galimberti, D.; Scarpini, E.; Bonuccelli, U.; Mancuso, M.; Siciliano, G.; Moebus, S.; Mecocci, P.; Zompo, M.; Maier, W.; Hampel, H.; Pilotto, A.; Frank‐García, A.; Panza, F.; Solfrizzi, V.; Caffarra, P.; Nacmias, B.; Perry, W.; Mayhaus, M.; Lannfelt, L.; Hakonarson, H.; Pichler, S.; Carrasquillo, M.; Ingelsson, M.; Beekly, D.; Álvarez, V.; Zou, F.; Valladares, O.; Younkin, S.; Coto, E.; Hamilton-Nelson, K.; Gu, W.; Razquín, C.; Pastor, P.; Mateo, I.; Owen, M.; Faber, K.; Jonsson, P.; Combarros, O.; O’Donovan, M.; Cantwell, L.; Soininen, H.; Blacker, D.; Mead, S.; Mosley, T.; Bennett, D.; Harris, T.; Fratiglioni, L.; Holmes, C.; F. de Bruijn, R.; Passmore, P.; Montine, T.; Bettens, K.; Rotter, J.; Brice, A.; Morgan, K.; Foroud, T.; Kukull, W.; Hannequin, D.; Powell, J.; Nalls, M.; Ritchie, K.; Lunetta, K.; Kauwe, J.; Boerwinkle, E.; Riemenschneider, M.; Boada, M.; Hiltunen, M.; Martin, E.; Schmidt, R.; Rujescu, D.; Dartigues, J.; Mayeux, R.; Tzourio, C.; Hofman, A.; Nöthen, M.; Graff, C.; Psaty, B.; Haines, J.; Lathrop, M.; Pericak-Vance, M.; Launer, L.; van Broeckhoven, C.; Farrer, L.; V. van Duijn, C.; Ramírez, A.; Seshadri, S.; Schellenberg, G.; Amouyel, P.; Williams, Julie

doi:10.1371/journal.pone.0094661

Public

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Shared by NobleBlocks on Jun 12, 2014 • 12:00 AM UTC

Authors:

V. Escott-Price

C. Bellenguez

Li-San Wang

Abstract

Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach whi...

Subject

Biology

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