The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

M, Olivier; A, Langerød; P, Carrieri; J, Bergh; S, Klaar; J, Eyfjord; C, Theillet; C, Rodriguez; R, Lidereau; I, Bièche; J, Varley; Y, Bignon; N, Uhrhammer; R, Winqvist; A, Jukkola-Vuorinen; D, Niederacher; S, Kato; C, Ishioka; P, Hainaut; AL, Børresen-Dale

doi:10.1158/1078-0432.ccr-05-1029

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

Shared by NobleBlocks on Feb 1, 2006 • 12:00 AM UTC

Authors:

Olivier M

Langerød A

Carrieri P

Abstract

To investigate the clinical value of somatic TP53 mutations in breast cancer, we assembled clinical and molecular data on 1,794 women with primary breast cancer with long-term follow-up and whose tumor has been screened for mutation in exons 5 to 8 of TP53 by gene sequencing. TP53 mutations were mor...

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