Role of histone H3 lysine 27 methylation in X inactivation.

K, Plath; J, Fang; SK, Mlynarczyk-Evans; R, Cao; KA, Worringer; H, Wang; la Cruz CC, de; AP, Otte; B, Panning; Y, Zhang

doi:10.1126/science.1084274

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Role of histone H3 lysine 27 methylation in X inactivation.

Shared by NobleBlocks on Mar 20, 2003 • 12:00 AM UTC

Authors:

Plath K

Fang J

Mlynarczyk-Evans SK

Abstract

The Polycomb group (PcG) protein Eed is implicated in regulation of imprinted X-chromosome inactivation in extraembryonic cells but not of random X inactivation in embryonic cells. The Drosophila homolog of the Eed-Ezh2 PcG protein complex achieves gene silencing through methylation of histone H3 on...

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