Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.

M, Shintani; Y, Ogawa; K, Ebihara; M, Aizawa-Abe; F, Miyanaga; K, Takaya; T, Hayashi; G, Inoue; K, Hosoda; M, Kojima; K, Kangawa; K, Nakao

doi:10.2337/diabetes.50.2.227

Public

Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.

Shared by NobleBlocks on Feb 1, 2001 • 12:00 AM UTC

Authors:

Shintani M

Ogawa Y

Ebihara K

Abstract

Ghrelin, an endogenous ligand for growth hormone secretagogue (GHS) receptor originally isolated from the stomach, occurs in the hypothalamic arcuate nucleus and may play a role in energy homeostasis. Synthetic GHSs have activated the hypothalamic arcuate neurons containing neuropeptide Y (NPY), sug...

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