Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals.

PJ, O'Brien; DE, Smith; TJ, Knechtel; MA, Marchak; I, Pruimboom-Brees; DJ, Brees; DP, Spratt; FJ, Archer; P, Butler; AN, Potter; JP, Provost; J, Richard; PA, Snyder; WJ, Reagan

doi:10.1258/002367706776319042

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Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals.

Shared by NobleBlocks on Apr 1, 2006 • 12:00 AM UTC

Authors:

O'Brien PJ

Smith DE

Knechtel TJ

Abstract

This study directly demonstrates that cardiac troponin I (cTnI) is a sensitive, specific, and persistent biomarker in laboratory animals. Histopathological and pathophysiological cardiac changes in dogs, rats and mice correlated with increased serum cTnI with various cardiac inotropic agents, and ca...

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