Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial.

P, Chetchotisakd; W, Chierakul; W, Chaowagul; S, Anunnatsiri; K, Phimda; P, Mootsikapun; S, Chaisuksant; J, Pilaikul; B, Thinkhamrop; S, Phiphitaporn; W, Susaengrat; C, Toondee; S, Wongrattanacheewin; V, Wuthiekanun; N, Chantratita; J, Thaipadungpanit; NP, Day; D, Limmathurotsakul; SJ, Peacock

doi:10.1016/s0140-6736(13)61951-0

Public

Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial.

Shared by NobleBlocks on Nov 25, 2013 • 12:00 AM UTC

Authors:

Chetchotisakd P

Chierakul W

Chaowagul W

Abstract

<h4>Background</h4>Melioidosis, an infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is difficult to cure. Antimicrobial treatment comprises intravenous drugs for at least 10 days, followed by oral drugs for at least 12 weeks. The standard oral regimen based on trial...

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