An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

Stemke-Hale, Katherine; Maria Gonzalez-Angulo, Ana; Lluch, Ana; M. Neve, Richard; Kuo, Wen-Lin; Davies, Michael; Carey, Mark; Hu, Zhi; Guan, Yinghui; Sahin, Aysegul; Fraser Symmans, W.; Pusztai, Lajos; K. Nolden, Laura; Horlings, Hugo; Berns, Katrien; Hung, Mien-Chie; J. van de Vijver, Marc; Valero, Vicente; W. Gray, Joe; Bernards, René; B. Mills, Gordon; T. Hennessy, Bryan

doi:10.1158/0008-5472.can-07-6854

Public

An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

Shared by NobleBlocks on Aug 1, 2008 • 12:00 AM UTC

Authors:

Katherine Stemke-Hale

Ana Maria Gonzalez-Angulo

Ana Lluch

Abstract

Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy–based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and P...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!