Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.

E, Charafe-Jauffret; C, Ginestier; F, Iovino; J, Wicinski; N, Cervera; P, Finetti; MH, Hur; ME, Diebel; F, Monville; J, Dutcher; M, Brown; P, Viens; L, Xerri; F, Bertucci; G, Stassi; G, Dontu; D, Birnbaum; MS, Wicha

doi:10.1158/0008-5472.can-08-2741

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.

Shared by NobleBlocks on Feb 3, 2009 • 12:00 AM UTC

Authors:

Charafe-Jauffret E

Ginestier C

Iovino F

Abstract

Tumors may be initiated and maintained by a cellular subcomponent that displays stem cell properties. We have used the expression of aldehyde dehydrogenase as assessed by the ALDEFLUOR assay to isolate and characterize cancer stem cell (CSC) populations in 33 cell lines derived from normal and malig...

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