Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.

Umezu-Goto, Makiko; Kishi, Yasuhiro; Taira, Akitsu; Hama, Kotaro; Dohmae, Naoshi; Takio, Koji; Yamori, Takao; B Mills, Gordon; Inoue, Keizo; Aoki, Junken; Arai, Hiroyuki

doi:10.1083/jcb.200204026

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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.

Shared by NobleBlocks on Jul 22, 2002 • 12:00 AM UTC

Authors:

Makiko Umezu-Goto

Yasuhiro Kishi

Akitsu Taira

Abstract

Autotaxin (ATX) is a tumor cell motility-stimulating factor, originally isolated from melanoma cell supernatants. ATX had been proposed to mediate its effects through 5'-nucleotide pyrophosphatase and phosphodiesterase activities. However, the ATX substrate mediating the increase in cellular motilit...

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