PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.

F, Shi; M, Shi; Z, Zeng; RZ, Qi; ZW, Liu; JY, Zhang; YP, Yang; P, Tien; FS, Wang

doi:10.1002/ijc.25397

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PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.

Published in International journal of cancer • Feb 1, 2011

Authors:

Shi F

Shi M

Zeng Z

Abstract

Programmed death 1 (PD-1) and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of cytotoxic CD8(+) T lymphocytes, the main effector cells in hepatocellular carcinoma (HCC) patients, are not well defined. In thi...

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