Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)

Ramsden, Martin; Kotilinek, Linda; Forster, Colleen; Paulson, Jennifer; McGowan, Eileen; SantaCruz, Karen; Guimaraes, Aaron; Yue, Mei; Lewis, Jada; Carlson, George; Hutton, Michael; H. Ashe, Karen

doi:10.1523/jneurosci.3279-05.2005

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Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)

Shared by NobleBlocks on Nov 16, 2005 • 12:00 AM UTC

Authors:

Martin Ramsden

Linda Kotilinek

Colleen Forster

Abstract

Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tau P301L )4510 mouse expresses the P301L mutation in tau (4R0N) associated with frontotemporal dementia and parkinsonism linked to chromosome 17. Transgene expression was driven by a forebrain-specific Ca...

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