In Vitro and In Vivo Activities of Anti-Influenza Virus Compound T-705

Furuta, Y.; Takahashi, K.; Fukuda, Y.; Kuno, M.; Kamiyama, T.; Kozaki, K.; Nomura, N.; Egawa, H.; Minami, S.; Watanabe, Y.; Narita, H.; Shiraki, K.

doi:10.1128/aac.46.4.977-981.2002

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In Vitro and In Vivo Activities of Anti-Influenza Virus Compound T-705

Shared by NobleBlocks on Apr 1, 2002 • 12:00 AM UTC

Authors:

Y. Furuta

K. Takahashi

Y. Fukuda

Abstract

ABSTRACT T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) has been found to have potent and selective inhibitory activity against influenza virus. In an in vitro plaque reduction assay, T-705 showed potent inhibitory activity against influenza A, B, and C viruses, with 50% inhibitory concentrations ...

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