DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

E, Soldaini; S, John; S, Moro; J, Bollenbacher; U, Schindler; WJ, Leonard

doi:10.1128/mcb.20.1.389-401.2000

Public

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

Shared by NobleBlocks on Jan 1, 2000 • 12:00 AM UTC

Authors:

Soldaini E

John S

Moro S

Abstract

We have defined the optimal binding sites for Stat5a and Stat5b homodimers and found that they share similar core TTC(T/C)N(G/A)GAA interferon gamma-activated sequence (GAS) motifs. Stat5a tetramers can bind to tandemly linked GAS motifs, but the binding site selection revealed that tetrameric bindi...

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