Herpes simplex virus encephalitis is a trigger of brain autoimmunity.

Armangue, Thaís; Leypoldt, Frank; Málaga, Ignacio; Raspall-Chaure, Miquel; Marti, Itxaso; Nichter, Charles; Pugh, John; Vicente-Rasoamalala, Monica; Lafuente-Hidalgo, Miguel; Macaya, Alfons; Ke, Michael; J Titulaer, Maarten; Höftberger, Romana; Sheriff, Heather; Glaser, Carol; Dalmau, Josep

doi:10.1002/ana.24083

Public

Herpes simplex virus encephalitis is a trigger of brain autoimmunity.

Shared by NobleBlocks on Feb 1, 2014 • 12:00 AM UTC

Authors:

Thaís Armangue

Frank Leypoldt

Ignacio Málaga

Abstract

In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spon...

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