Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

JJ, Yang; W, Landier; W, Yang; C, Liu; L, Hageman; C, Cheng; D, Pei; Y, Chen; KR, Crews; N, Kornegay; FL, Wong; WE, Evans; CH, Pui; S, Bhatia; MV, Relling

doi:10.1200/jco.2014.59.4671

Public

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

Shared by NobleBlocks on Jan 26, 2015 • 12:00 AM UTC

Authors:

Yang JJ

Landier W

Yang W

Abstract

<h4>Purpose</h4>Mercaptopurine (MP) is the mainstay of curative therapy for acute lymphoblastic leukemia (ALL). We performed a genome-wide association study (GWAS) to identify comprehensively the genetic basis of MP intolerance in children with ALL.<h4>Patients and methods</h4>The discovery GWAS and...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!