Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.

Y, He; K, Kozaki; T, Karpanen; K, Koshikawa; S, Yla-Herttuala; T, Takahashi; K, Alitalo

doi:10.1093/jnci/94.11.819

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Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.

Shared by NobleBlocks on Jun 1, 2002 • 12:00 AM UTC

Authors:

He Y

Kozaki K

Karpanen T

Abstract

<h4>Background</h4>Vascular endothelial growth factor C (VEGF-C) stimulates tumor lymphangiogenesis (i.e., formation of lymphatic vessels) and metastasis to regional lymph nodes by interacting with VEGF receptor 3 (VEGFR-3). We sought to determine whether inhibiting VEGFR-3 signaling, and thus tumor...

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