Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy.

Ferreira, F; Hirtenlehner, K; Jilek, A; Godnik-Cvar, J; Breiteneder, H; Grimm, R; Hoffmann-Sommergruber, K; Scheiner, O; Kraft, D; Breitenbach, M; J Rheinberger, H; Ebner, C

doi:10.1084/jem.183.2.599

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Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy.

Shared by NobleBlocks on Feb 1, 1996 • 12:00 AM UTC

Authors:

F Ferreira

K Hirtenlehner

A Jilek

Abstract

We dissected the T cell activation potency and the immunoglobulin (Ig) E-binding properties (allergenicity) of nine isoforms of Bet v 1 (Bet v 1a-Bet v 1l), the major birch pollen allergen. Immunoblot experiments showed that Bet v 1 isoforms differ in their ability to bind IgE from birch pollen-alle...

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