Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial.

Burmester, Gerd-Rűdiger; J Kivitz, Alan; Kupper, Hartmut; Arulmani, Udayasankar; Florentinus, Stefan; L Goss, Sandra; S Rathmann, Suchitrita; M Fleischmann, Roy

doi:10.1136/annrheumdis-2013-204769

Public

Efficacy and safety of ascending methotrexate dose in combination with adalimumab: the randomised CONCERTO trial.

Shared by NobleBlocks on Jun 1, 2015 • 12:00 AM UTC

Authors:

Gerd-Rűdiger Burmester

Alan J Kivitz

Hartmut Kupper

Abstract

OBJECTIVE: CONCERTO was a randomised, double-blind, parallel-armed study of methotrexate (MTX) in combination with adalimumab to assess whether an increasing trend of efficacy and decreased safety exists when increasing MTX dose in patients with early rheumatoid arthritis (RA). METHODS: Early, biolo...

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