Pharmacodynamics of active site-inhibited factor VIIa in endotoxin-induced coagulation in humans.

B, Jilma; C, Marsik; F, Mayr; MT, Graninger; FB Jr, Taylor; MC, Ribel; E, Erhardtsen; S, Handler; HG, Eichler

doi:10.1067/mcp.2002.127740

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Pharmacodynamics of active site-inhibited factor VIIa in endotoxin-induced coagulation in humans.

Shared by NobleBlocks on Oct 1, 2002 • 12:00 AM UTC

Authors:

Jilma B

Marsik C

Mayr F

Abstract

<h4>Background</h4>Inhibition of the tissue factor-factor VIIa pathway attenuated the activation of coagulation and prevented death in a gram-negative bacteremia primate model of sepsis. This lethal animal model suggested that tissue factor also influences inflammatory cascades.<h4>Methods</h4>This ...

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