Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-.

M, Mallo; L, Arenillas; B, Espinet; M, Salido; JM, Hernández; E, Lumbreras; Rey M, del; E, Arranz; S, Ramiro; P, Font; O, González; M, Renedo; J, Cervera; E, Such; GF, Sanz; E, Luño; C, Sanzo; M, González; MJ, Calasanz; J, Mayans; C, García-Ballesteros; V, Amigo; R, Collado; I, Oliver; F, Carbonell; E, Bureo; A, Insunza; L, Yañez; MJ, Muruzabal; E, Gómez-Beltrán; R, Andreu; P, León; V, Gómez; A, Sanz; N, Casasola; E, Moreno; A, Alegre; ML, Martín; C, Pedro; S, Serrano; L, Florensa; F, Solé

doi:10.3324/haematol.13012

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Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-.

Shared by NobleBlocks on Jul 1, 2008 • 12:00 AM UTC

Authors:

Mallo M

Arenillas L

Espinet B

Abstract

<h4>Background</h4>More than 50% of patients with myelodysplastic syndromes present cytogenetic aberrations at diagnosis. Partial or complete deletion of the long arm of chromosome 5 is the most frequent abnormality. The aim of this study was to apply fluorescence in situ hybridization of 5q31 in pa...

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