Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia.

Raa GD, te; J, Malcikova; S, Pospisilova; M, Trbusek; M, Mraz; ML, Garff-Tavernier; H, Merle-Béral; K, Lin; AR, Pettitt; O, Merkel; T, Stankovic; Oers MH, van; E, Eldering; S, Stilgenbauer; T, Zenz; AP, Kater

doi:10.3109/10428194.2013.796058

Public

Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia.

Shared by NobleBlocks on Jun 24, 2013 • 12:00 AM UTC

Authors:

te Raa GD

Malcikova J

Pospisilova S

Abstract

The ATM-p53 DNA damage response pathway plays a crucial role in chemoresistance in chronic lymphocytic leukemia, as indicated by the adverse prognostic impact of deletions of 17p (locus of TP53) and 11q (locus of ATM) detected by fluorescence in situ hybridization (FISH) analysis. In addition to del...

Discussions