Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial

D. Brown, Paul; Pugh, S.; N. Laack, Nadia; S. Wefel, Jeffrey; Khuntia, Deepak; Meyers, Christina; Choucair, Ali; Fox, Sherry; H. Suh, John; Roberge, David; S. Kavadi, Vivek; M. Bentzen, Søren; P. Mehta, Minesh; Watkins Bruner, Deborah; the Radiation Therapy Oncology Group (RTOG), for

doi:10.1093/neuonc/not114

Public

Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial

Published in Neuro-Oncology • Aug 16, 2013

Authors:

Paul D. Brown

S. Pugh

Nadia N. Laack

Abstract

BACKGROUND: To determine the protective effects of memantine on cognitive function in patients receiving whole-brain radiotherapy (WBRT). METHODS: Adult patients with brain metastases received WBRT and were randomized to receive placebo or memantine (20 mg/d), within 3 days of initiating radiotherap...

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Open Access

Subject

Memantine

Medicine

Placebo

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