IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.

E, Lubberts; den Bersselaar L, van; B, Oppers-Walgreen; P, Schwarzenberger; Roo CJ, Coenen-de; JK, Kolls; LA, Joosten; den Berg WB, van

doi:10.4049/jimmunol.170.5.2655

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IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.

Shared by NobleBlocks on Mar 1, 2003 • 12:00 AM UTC

Authors:

Lubberts E

van den Bersselaar L

Oppers-Walgreen B

Abstract

IL-17 is a T cell-derived proinflammatory cytokine in experimental arthritis and is a stimulator of osteoclastogenesis in vitro. In this study, we report the effects of IL-17 overexpression (AdIL-17) in the knee joint of type II collagen-immunized mice on bone erosion and synovial receptor activator...

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