Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis

Spindler, Matthias; Meyer, Klaus; Strömer, Hinrik; Leupold, Andrea; Boehm, Ernest; Wagner, Helga; Neubauer, Stefan

doi:10.1152/ajpheart.01016.2003

Public

Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis

Shared by NobleBlocks on Apr 27, 2004 • 12:00 AM UTC

Authors:

Matthias Spindler

Klaus Meyer

Hinrik Strömer

Abstract

The creatine kinase (CK) system is involved in the rapid transport of high-energy phosphates from the mitochondria to the sites of maximal energy requirements such as myofibrils and sarcolemmal ion pumps. Hearts of mice with a combined knockout of cytosolic M-CK and mitochondrial CK (M/Mito-CK(-/-))...

Subject

Internal medicine

Homeostasis

Creatine kinase

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