Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.

<h4>Context</h4>Mouse knockout models have clearly demonstrated the critical importance of IGF-I and IGF receptor type 1 (IGF-IR) for embryonic growth as well as postnatal growth.<h4>Objective</h4>We hypothesized that mutations of IGF-IR gene might predispose to short stature in children born with i... View More